Numerous updates have been issued to OECD’s guidelines for the testing of chemicals. The methods cover in vitro and in vivo tests for a wide range of toxicity endpoints.
- TG 404: acute dermal irritation/corrosion
- TG 421: reproduction/developmental toxicity screening test
- TG 422: combined repeated dose toxicity study with the reproduction/developmental toxicity screening test
- TG 430: in vitro skin corrosion: Transcutaneous Electrical Resistance test method (TER)
- TG 431: In vitro skin corrosion: Reconstructed Human Epidermis (RHE) test method
- TG 435: in vitro membrane barrier test method for skin corrosion
- TG 439: in vitro skin irritation: reconstructed human epidermis test method
- TG 476: in vitro mammalian cell gene mutation tests using the Hprt and xprt genes
- TG 478: rodent dominant lethal test
- TG 483: mammalian spermatogonial chromosomal aberration test
- TG 490: in vitro mammalian cell gene mutation tests using the thymidine kinase gene.
- TG 491: short time exposure in vitro test method for identifying i) chemicals inducing serious eye damage and ii) chemicals not requiring classification for eye irritation or serious eye damage
- TG 492: Reconstructed human Cornea-like Epithelium (RhCE) test method for identifying chemicals not requiring classification and labelling for eye irritation or serious eye damage
- TG 493: performance-based test guideline for human recombinant Estrogen Receptor (hrER) in vitro assays to detect chemicals with ER binding affinity.
In addition, OECD has released a draft update to TG 455, the performance-based test guideline for stably transfected transactivation in vitro assays to detect oestrogen receptor agonists and antagonists.
Organisation for Economic Co-operation and Development (2015). Guidelines for the testing of chemicals.
The above items were taken from the October 2015 issue of Toxicology and Regulatory News which is sent automatically to members of bibra (click here)News Home Guest Write For Us? Contact Us