Numerous updates have been issued to OECD’s guidelines for the testing of chemicals. The methods cover in vitro and in vivo tests for a wide range of toxicity endpoints.

  • TG 404: acute dermal irritation/corrosion
  • TG 421: reproduction/developmental toxicity screening test
  • TG 422: combined repeated dose toxicity study with the reproduction/developmental toxicity screening test
  • TG 430: in vitro skin corrosion: Transcutaneous Electrical Resistance test method (TER)
  • TG 431: In vitro skin corrosion: Reconstructed Human Epidermis (RHE) test method
  • TG 435: in vitro membrane barrier test method for skin corrosion
  • TG 439: in vitro skin irritation: reconstructed human epidermis test method
  • TG 476: in vitro mammalian cell gene mutation tests using the Hprt and xprt genes
  • TG 478: rodent dominant lethal test
  • TG 483: mammalian spermatogonial chromosomal aberration test
  • TG 490: in vitro mammalian cell gene mutation tests using the thymidine kinase gene.
  • TG 491: short time exposure in vitro test method for identifying i) chemicals inducing serious eye damage and ii) chemicals not requiring classification for eye irritation or serious eye damage
  • TG 492: Reconstructed human Cornea-like Epithelium (RhCE) test method for identifying chemicals not requiring classification and labelling for eye irritation or serious eye damage
  • TG 493: performance-based test guideline for human recombinant Estrogen Receptor (hrER) in vitro assays to detect chemicals with ER binding affinity.

In addition, OECD has released a draft update to TG 455, the performance-based test guideline for stably transfected transactivation in vitro assays to detect oestrogen receptor agonists and antagonists.

Organisation for Economic Co-operation and Development (2015). Guidelines for the testing of chemicals.

http://www.oecd-ilibrary.org/environment/oecd-guidelines-for-the-testing-of-chemicals-section-4-health-effects_20745788

 

The above items were taken from the October 2015 issue of Toxicology and Regulatory News which is sent automatically to members of bibra (click here)

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