A final EPA review considers the types, causes and underlying mechanisms of lymphohaematopoietic cancers. The report focuses in particular on leukaemia-inducing agents, and summarises the relevant data on several chemicals, including:

  • ethylene oxide
  • 1,3-butadiene
  • formaldehyde (for which short overviews are presented)
  • benzene

A discussion on the use of mechanistic information of leukaemia-inducing agents to inform the risk assessment process also features.

US Environmental Protection Agency (EPA). National Center for Environmental Assessment (NCEA).
Lymphohematopoietic cancers induced by chemicals and other agents: overview and implications for risk assessment (Final Report). EPA/600/R-10/095F, July 2012.

http://cfpub.epa.gov/ncea/cfm/recordisplay.cfm?deid=239589

 

The above item was taken from the August 2012 issue of Toxicology and Regulatory News which is sent automatically to members of bibra (click here for more details).

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