A final NTP technical report on the toxicology of Ginkgo biloba extract has recently been made available. Extracts from leaves of the Ginkgo biloba tree are used in complementary medicine, for example to improve brain function and reduce the risk of cardiovascular disease. In 2-year gavage studies, clear evidence of carcinogenic activity was seen in mice, based on an increased incidence of liver tumours. In addition, some evidence of carcinogenic activity (an increased incidence of thyroid tumours) was observed in rats. Non‑neoplastic lesions were also recorded in several tissues. Evidence of mutagenic activity was seen in Salmonella typhimurium (two strains) and in Escherichia coli (one strain), with and without metabolic activation, but there was no significant evidence of chromosome damage in a 3-month mouse micronucleus test. The results of associated studies, as well as a comprehensive review of other pertinent data, are also presented.

US National Toxicology Program. NTP technical report on the toxicology and carcinogenesis studies of Ginkgo biloba extract (CAS No. 90045-36-6) in F344/N rats and B6C3F1/N mice (gavage studies).

NTP TR 578, March 2013.



The above item was taken from the May 2013 issue of Toxicology and Regulatory News which is sent automatically to members of bibra (click here for more details).

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