A final NTP technical report on toxicology and carcinogenicity studies has recently been issued on N,N‑dimethyl-p-toluidine, a substance used in dental materials and bone cements. There was clear evidence of carcinogenic activity in 2-year oral gavage studies (of up to 60 mg/kg bw/day) in male and female rats and mice, based on increased incidences of tumours in the liver, nose and lung. Non-neoplastic effects were also seen, including in the bone marrow, kidney and spleen. The results of associated investigations undertaken by the NTP (3‑month and 4-day studies in rats and mice and genotoxicity assays) are also presented, together with a review of pertinent toxicity information.

US National Toxicology Program. NTP technical report on the toxicology and carcinogenesis studies of N,N-dimethyl-p– toluidine in F344/N rats and B6C3F1/N mice (gavage studies).
NTP TR 579, September 2012.

http://ntp.niehs.nih.gov/ntp/htdocs/LT_rpts/TR579_508.pdf

 

The above item was taken from the October 2012 issue of Toxicology and Regulatory News which is sent automatically to members of bibra (click here for more details).

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