A final NTP technical report on toxicology and carcinogenicity studies has recently been issued on N,N‑dimethyl-p-toluidine, a substance used in dental materials and bone cements. There was clear evidence of carcinogenic activity in 2-year oral gavage studies (of up to 60 mg/kg bw/day) in male and female rats and mice, based on increased incidences of tumours in the liver, nose and lung. Non-neoplastic effects were also seen, including in the bone marrow, kidney and spleen. The results of associated investigations undertaken by the NTP (3‑month and 4-day studies in rats and mice and genotoxicity assays) are also presented, together with a review of pertinent toxicity information.

US National Toxicology Program. NTP technical report on the toxicology and carcinogenesis studies of N,N-dimethyl-p– toluidine in F344/N rats and B6C3F1/N mice (gavage studies).
NTP TR 579, September 2012.



The above item was taken from the October 2012 issue of Toxicology and Regulatory News which is sent automatically to members of bibra (click here for more details).

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