A final NTP technical report on the toxicology of trimethylolpropane triacrylate (TMPTA) has recently been made available. TMPTA has a wide variety of industrial uses, including inks, resins, coatings and the production of superabsorbent nappies. In 2-year dermal studies, equivocal evidence of carcinogenic activity was seen in male rats based on marginally increased incidence of malignant mesothelioma. There was also some evidence of carcinogenic activity in female mice based on the occurrence of tumours in the uterus and uncommon malignant neoplasms in the liver. Non-neoplastic skin lesions were also recorded at the site of administration. No evidence of mutagenic activity was seen in a bacterial reverse mutation (Ames) assay. The results of other associated studies, as well as a comprehensive review of other pertinent data, are also presented.

US National Toxicology Program. NTP technical report on the toxicology and carcinogenesis studies of trimethylolpropane triacrylate in F344/N rats and B6C3F1/N mice (dermal studies). NTP TR 576, December 2012.

http://ntp.niehs.nih.gov/ntp/htdocs/LT_rpts/TR576_508.pdf

 

The above item was taken from the March 2013 issue of Toxicology and Regulatory News which is sent automatically to members of bibra (click here for more details).

 

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