A final technical report on the toxicology of pyrogallol has recently been made available by the US National Toxicology Program. While it is currently used widely in pharmaceutical and chemical synthesis, pyrogallol has a history of use in textiles and hair dyes. In a two-year dermal study on rats and mice given 0, 5, 20 or 75 mg/kg bw/day, 5 days a week, the skin was shown to be the primary site of toxicity, with dose-dependent increases in non-neoplastic lesions reported (including hyperplasia, hyperkeratosis and inflammation). In high-dose female mice, there was some evidence of local carcinogenicity, based on increased incidences of squamous cell carcinoma. Evidence for carcinogenicity in high-dose male mice (based on an increased incidence of squamous cell papilloma) was considered equivocal. No evidence of carcinogenicity was seen in rats. The results of genotoxicity and other pertinent studies are also presented.

US National Toxicology Program. NTP technical report on the toxicology and carcinogenesis studies of pyrogallol (CAS no. 87 66-1) in F344/N rats and B6C3F1/N mice (dermal studies).

NTP TR 574, February 2013.

http://ntp.niehs.nih.gov/ntp/htdocs/LT_rpts/TR574_508.pdf

 

The above item was taken from the April 2013 issue of Toxicology and Regulatory News which is sent automatically to members of bibra (click here for more details).

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