…styrene-acrylonitrile trimer…

A final NTP technical report on toxicology and carcinogenicity studies has recently been issued on styrene-acrylonitrile trimer (SAN-trimer), a by-product formed during the manufacture of acrylonitrile styrene plastics. No evidence of carcinogenicity was found in male and female rats fed diets containing SAN-trimer at up to 1600 ppm (about 80 mg/kg bw/day) for 2 years (including during gestation and lactation). Non-neoplastic effects (including peripheral nerve degeneration and bone marrow and urinary bladder hyperplasia) were seen. The results of associated investigations undertaken by the NTP (including 7- and 18-week repeated dose toxicity studies in rats and genotoxicity assays) are also presented in this final report, together with a review of pertinent toxicity information.

US National Toxicology Program (NTP). Toxicology and carcinogenesis study of styrene-acrylonitrile trimer (SAN-Trimer) in F344/N rats (perinatal and postnatal feed studies).
NTP TR 573, July 2012



…and acrylamide

According to the final NTP report on acrylamide, there was clear evidence of carcinogenic activity in 2-year drinking water studies in male and female rats and mice, based on increased incidences of tumours in multiple organs. At the lowest tested dose of around 0.4 mg/kg bw/day in rats and 1 mg/kg bw/day in mice there were, respectively, increased incidences of clitoral gland carcinomas in females and harderian gland adenomas in both sexes. The results of associated investigations undertaken by the NTP (2-week and 3‑month studies) are also presented, together with a review of pertinent toxicity information.

[US National Toxicology Program. NTP technical report on the toxicology and carcinogenesis studies of acrylamide in F344/N rats and B6C3F1 mice (feed and drinking water studies).
NTP TR 575, July 2012



The above item was taken from the August 2012 issue of Toxicology and Regulatory News which is sent automatically to members of bibra (click here for more details).

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