Enthusiastically welcomed by many risk assessors, the threshold of toxicological concern (TTC) concept centres on the idea that, even for chemicals with incomplete toxicological profiles, it is possible to predict an exposure level below which there is no appreciable risk to human health. A weighty report of around 750 pages has now been published by EFSA that discusses how the applicability of TTC schemes (for both carcinogenic and non-carcinogenic end-points) could be improved by incorporating physicochemical data and toxicity data generated by non-testing methods such as QSARs and read-across within structurally related chemical groups. Overall, the described methodology appeared to be viewed favourably, although further analyses were recommended.

[Bassan A. et al. (2011). Scientific report submitted to EFSA. Applicability of physicochemical data, QSARs and read-across in threshold of toxicological concern assessment. S-IN Soluzioni Informatiche. Accepted for publication at http://www.efsa.europa.eu/en/supporting/doc/159e.pdf on 7 June 2011 on the website of the European Food Safety Authority.] {187973}

The above item was taken from the August 2011 issue of Toxicology and Regulatory News which is sent automatically to members of bibra (click here for more details).

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