ECHA has recently prepared scientific opinions on occupational exposure to diisocyanates and lead (including lead compounds). An 8-hour (time-weighted average) occupational exposure limit (OEL) of 30 μg/m3 was proposed for lead and its (inorganic and organic) compounds, with the stated aim of achieving a blood lead level below 150 μg/L. The Agency did, however, highlight the potential for effects on cognitive function development in newborns as an area of concern, and made specific recommendations to address this concern. No OEL value for diisocyanates was proposed,

notably as the data were not considered adequate for determining a threshold for the induction or elicitation of respiratory sensitisation. ECHA “proposes to further develop the approach to derive an exposure response and then establish an OEL”.

European Chemicals Agency (2019). ECHA Scientific reports for evaluation of limit values at the workplace. Reports available via:


The above items were taken from the November 2019 issue of Toxicology and Regulatory News which is sent automatically to members of bibra.

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