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Developmental neurotoxicity (DNT) testing – is industry doing enough?

Developmental neurotoxicity (DNT) testing – is industry doing enough?

Neurodevelopmental disorders in children have increased significantly in recent years (according to the European Joint Research Centre), which adds urgency to the need to evaluate new and existing chemicals for their potential activity in this area. This is difficult when the existing OECD DNT study,…

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The Threshold of Toxicological Concern (TTC) approach to risk assessment: “Origins”

The Threshold of Toxicological Concern (TTC) approach to risk assessment: “Origins”

The regulators love the TTC approach, which essentially uses a knowledge of the toxicological properties of the universe of tested chemicals to make conservative predictions of the likely toxicity of untested materials. It gives them pragmatic respite from the onward march of analytical chemistry (ever-increasing…

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Public Health England reviews the evidence on e-cigarettes and heated tobacco

Public Health England reviews the evidence on e-cigarettes and heated tobacco

The effects of vaping on public health remains a newsworthy and interesting topic of discussion, with a range of views and opinions. Public Health England (PHE) is committed to reviewing the evidence regarding e-cigarette use and the effects of vaping on consumer health. PHE has…

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EFSA/ECHA guidance on identifying endocrine disruptors (EDs)

EFSA/ECHA guidance on identifying endocrine disruptors (EDs)

Hormonal disruption is a hot topic these days. Following 2016 draft EU legislation setting scientific criteria for identifying EDs (under plant protection and biocidal products Regulations), EFSA and ECHA have issued a draft guidance document on this subject. It includes advice on how to gather,…

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End of the line for the in vivo unscheduled DNA synthesis (UDS) assay?

End of the line for the in vivo unscheduled DNA synthesis (UDS) assay?

Establishing whether or not a substance is genotoxic is critical in risk assessment, as it determines whether the substance can be assessed as a threshold or non-threshold toxin. The OECD Test Guidelines (TGs) on genetic toxicology are considered the “gold standard” on how the favoured…

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Updating REACH dossiers – the whys and hows

Updating REACH dossiers – the whys and hows

Following on from our last blog about ECHA-instigated updates to REACH registration dossiers (e.g. following an ECHA Evaluation (draft) decision), it’s worth taking a look at the update process more generally: Why are updates so important and how should we go about actioning them? A…

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QRA 2: The SCCS puts skin sensitisation risk assessment to the test

QRA 2: The SCCS puts skin sensitisation risk assessment to the test

Feeling a bit itchy? Skin sensitisation from fragrance ingredients in cosmetics, personal care products and household goods is relatively common and causes considerable concern for fragrance manufacturers and regulators. The QRA2 model, developed by the International Fragrance Association as part of the International Dialogue for…

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Gold, frankincense, myrrh, lead, cadmium…

Gold, frankincense, myrrh, lead, cadmium…

With Halloween behind us and Christmas on the horizon, many of us have succumbed to the high street’s festive-themed homeware; including decorated drinking glasses. The University of Plymouth recently released the results of a study testing new and second-hand glasses with decorative enamel for the…

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Toxicological risk assessment – the intelligent way to evaluate medical devices

Toxicological risk assessment – the intelligent way to evaluate medical devices

From adhesive bandages to audiometers, container-closure systems to catheters, and stethoscopes to scalpels – medical devices cover an impressive range of healthcare products. Of course, different types of medical device have varying levels of human health risk associated with them. For example, examination gloves worn…

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Registration – the end of the road? Evaluation is here…

Registration – the end of the road? Evaluation is here…

After the long and often arduous process of submitting a REACH registration, registrants might be forgiven for thinking that their work is done following receipt of a REACH registration number, with no necessity for future action. In reality, ECHA makes a point of assessing certain…

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